Antigenic specificity of the Mycobacterium leprae homologue of ESAT-6.

نویسندگان

  • John S Spencer
  • Maria Angela M Marques
  • Monica C B S Lima
  • Ana Paula Junqueira-Kipnis
  • Bruce C Gregory
  • Richard W Truman
  • Patrick J Brennan
چکیده

The sequence of the Mycobacterium leprae homologue of ESAT-6 shows only 36% amino acid correspondence to that from Mycobacterium tuberculosis. Anti-M. leprae ESAT-6 polyclonal and monoclonal antibodies and T-cell hybridomas reacted only with the homologous protein and allowed identification of the B- and T-cell epitopes. The protein is expressed in M. leprae and appears in the cell wall fraction. Thus, M. leprae ESAT-6 shows promise as a specific diagnostic agent for leprosy.

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عنوان ژورنال:
  • Infection and immunity

دوره 70 2  شماره 

صفحات  -

تاریخ انتشار 2002